Often used as a QC parameter for cells in scRNA-seq data. The higher the fraction of mitochondrial expression (i.e. of expression coming from mitochondrial genes), the higher the implied level of stress a cell is in and by consequence the lower the assumed quality. In scRNAseq cancer data, a cutoff of 0.25 is often used although any individual value is always arbitrary and one is better off plotting the data. note: the list of mitochondrial genes are those that start with "MT".

frac_mito(m)

Arguments

m

matrix of expression values to test